Industry Sponsored Research

ONGOING

No.	Research Title	Investigator	Status
1	AEGIS II – A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Efficacy and Safety of CSL112 in Subject with Acute Coronary Syndrome	Dato’ Sri Dr. Haji Azhari Rosman	Enrollment
2	APPIRED III – Preventing Oxidative Stress Induced Ischemic Injury and Systemic Inflammation Complications During and After Invasive Cardiac Surgery with Alkaline Phosphatase	Dr. Pau Kiew Kong	Enrollment
3	BIOFREEDOM – Asian Registry of the BioFreedom™ BA9™ Drug-Coated Coronary Stent for Patients with ST Elevation Myocardial Infarction (STEMI) Undergoing Percutaneous Coronary Intervention (PCI)	Dato’ Dr. Amin Ariff Nuruddin	Enrollment
4	BIOSOLVE -IV – Safety and Performance in de Novo Lesion of NatiVE Coronary Arteries with Magmaris-Registry	Dato’ Dr. Amin Ariff Nuruddin	Enrollment
5	CRYO-AF– Cryo AF Global Registry Study	Dr. Surinder Kaur Khelae	Enrollment
6	CTQJ230A12001 – Multi-center Cross-sectional Epidemiological Study to Characterize the Prevalence and Distribution of Lipoprotein(a) Levels Among Patients with Established Cardiovascular Disease	Datuk Dr. Ahmad Khairuddin Mohamed Yusof	Enrollment
7	DE NOVO – Treatment of Coronary De-Novo Stenosis by A Sirolimus Coated Balloon or A Paclitaxel Coated Balloon Catheter	Dato’ Dr. Amin Ariff Nuruddin	Enrollment
8	DEDICATE REGISTRY – A Post Market Registry of Abluminum® Sirolimus Eluting Coronary Stent System for Percutaneous Intervention in Patients with Diabetic Mellitus	Dato’ Sri Dr. Haji Azhari Rosman	Enrollment
9	EASTBOURNE – The All-comers Sirolimus Coated Balloon European Registry:	Dato’ Dr. Amin Ariff Nuruddin	Enrollment
10	FIM-IBS – A Prospective, Non-randomized, Open lable, Non-comparative, First-in-Man Study to Evaluate the Feasibility and Safety of Sirolimus-eluting Iron Bioresorbable Coronary Scaffold System	Dr. Shaiful Azmi Yahaya	Enrollment
11	NALURI – The Effectiveness of a Personalised Malaysian Digital Health Intervention (Naluri) on Physical and Psychological Outcomes among Cardiac Patients at the Malaysian National Institute: A Randomized Controlled Trial	Dato’ Dr. Azmee Mohd Ghazi	Enrollment
12	PROTECT-ICD – Programmed Ventricular Stimulation to Risk Stratify for Early Cardioverter-Defibrillator (ICD) Implantation to Prevent Tachyarrhythmias Following Acute Myocardial Infarction	Dr. Surinder Kaur Khelae	Enrollment
13	SELECT – Semaglutide Effects on Cardiovascular Outcomes in People with Overweight or Obesity	Dato’ Sri Dr. Haji Azhari Rosman	Enrollment
14	SELEXIPAG – A Prospective, Multicentre, Open Label, Single Arm, Phase 2 Study to Investigate the Safety, Tolerability and Pharmacokinetics of Selexipag in Children with Pulmonary Arterial Hypertention	Dr. Geetha A/P Kandavello @ Kandhavel	Enrollment
15	TOMORROW – A Multicenter, Open-label, Randomized, Event-driven Study to Assess Efficacy, Safety and Pharmacokinetics of Macitentan Versus Standard of Care in Children with Pulmonary Arterial Hypertension	Dr. Geetha A/P Kandavello @ Kandhavel	Enrollment
16	VFAHF STUDY – Ventricle from Atrium Heart Failure Clinical Study (VFAHF)	Dr. Azlan Hussin	Enrollment

No.	Research Title	Investigator	Status
1	AC-055-512 RETRO – A Retrospective, Multicenter Chart Review to Collect Dosing Information of PAH Background Medication in Subjects Who Participated in the AC-055-302 (SERAPHIN) Double-Blind Randomized Study	Dr. Geetha A/P Kandavello @ Kandhavel	Follow Up
2	ACOSYM – Prospective Observational study of Lipid management in South East Asian Patients who have a Recent Acute Coronary Syndrome Event	Dr. Emily Lay Koon Tan	Follow Up
3	ASIAN HF – Asian Sudden Cardiac Death in Heart Failure (ASIAN HF) Prospective Observational Registry	Dato’ Dr Azmee Mohd Ghazi	Follow Up
4	ASQuad – Attain StabilityTM Quad Clinical Study	Dr. Azlan Hussin	Follow Up
5	BIOFLOW-III Registry – Safety and Performance Registry for an all-comers Diabetic patient population with the Limus Eluting Orsiro Stent System within daily clinical practice – III	Dr. Shaiful Azmi Yahaya	Follow Up
6	BIOLUX P-III Registry – A Prospective, International, Multi-centre, Post-market All-Comers Registry to Assess the Clinical Performance of The Passeo-18 Lux Paclitaxel Releasing Balloon Catheter in Infraguinal Arteries	Dr. Shaiful Azmi Yahaya	Follow Up
7	CONSEQUENT ALL COMERS Registry – Clinical Post Market Clinical Follow-Up (PMCF) on Peripheral Arteries treated with Sequent ® Please OTW Paclitaxel Coated Ballon Catheter in an All Comer Patient Population	Dr. Shaiful Azmi Yahya	Follow Up
8	GRIPHON OL – Long Term, Single-Arm, Open-Label Study, to Assess the Safety and Tolerability of ACT-293987 in Patients with Pulmonary Arterial Hypertension	Dr. Teoh Chee Kiang	Follow Up
9	ISAR Neo – Coroflex ISAR Neo Registry in Malaysia	Dato’ Dr. Amin Ariff Nuruddin	Follow Up
10	ISCHEMIA – International Study of Comparative Health Effectiveness with Medical and Invasive Approaches	Datuk Dr. Ahmad Khairuddin Mohamed Yusof	Follow Up
11	MeRes – 1 Extend – A Prospective, Multicentre, Single arm, Open label, Pilot Clinical Study of MeRes100 Sirolimus Eluting Bioreorbable Vascular Caffold System in the Treatment of de-novo Native Coronary Artery Lesions	Dato’ Dr. Amin Ariff Nuruddin	Follow Up
12	MPP – Product Surveillance Registry – Multiple Point Pacing (MPP) Post Approval Study	Dr. Azlan Hussin	Follow Up
13	Onyx ONE – A Randomized Controlled Trial with Resolute Onyx in One Month DAPT for High-Bleeding Risk Patients	Dato’ Dr. Amin Ariff Nuruddin	Follow Up
14	PARADIGM-HF – A Multicenter Study to Evaluate Safety and Tolerability in Patients with Chronic Heart Failure and Reduced Enjection Fraction from PARADIGM-HF receiving Open Label LCZ696	Dr. Ng Yau Piow	Follow Up
15	PASSWORD Registry – Post market Surveillance of SeQuent® Please Neo with Scoring Ballon Lesion Preparation in Real World Patients	Datuk Dr. Ahmad Khairuddin Mohamed Yusof	Follow Up
16	REPAIR – Right vEntricular remodeling in Pulmonary ArterIal hypeRtension A prospective, multicenter, single-arm, open-label, Phase 4 study to evaluate the effects of macitentan on Right vEntricular remodeling in Pulmonary ArterIal hypeRtension assessed by cardiac magnetic resonance imaging	Dr. Geetha A/P Kandavello @ Kandhavel	Follow Up
17	SAMURAI – ImageReady™ MR Conditional Pacing System Clinical Study	Dr. Surinder Kaur Khelae	Follow Up
18	UNIVERSE – A Prospective, Open-Label, Active-Controlled Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety, and Efficacy of Rivaroxaban for Thromboprophylaxis in Pediatric Subject 2 to 8 Years of Age after the Fontan Procedure	Dr. Hasri Samion	Follow Up
19	VITALITY-HFpEF – A Randomized Parallel-group, Placebo-controlled, Double-blind, Multi-centre Trial to Evaluate the Efficacy and Safety of the Oral SGC Stimulator Vericiguat to Improve Physical Functioning in Activities of Daily Living in Patients with Heart Failure and Preserved Ejection Fraction	Dr. Teoh Chee Kiang	Follow Up
20	XPLORE-1 – Prospective, Non-Randomised, Open-label Clinical Study to Assess the Safety of the Bioabsorbable Pulmonary Valve Conduit (PV-001) in Subjects Undergoing Right Ventricular Outflow Tract (RVOT) Reconstruction	Dato’ Seri Dr. Mohd Azhari Yakub	Follow Up

COMPLETED